However, in contrast to our initial hypothesis, and to literature reports invoking these alkoxyphosphonium salts as key intermediates, we did not find that the phosphine oxide is beneficial in the glycosylation step in our system. When glycosyl chloride 6a was synthesised as normal and then the Ph3PO removed prior to glycosylation, excellent β-selectivity was still obtained (entry 1).
Bedini Sg Intermediate Pdf 16
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